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Furthermore we argued that an inability to encode or
2022-04-08

Furthermore, we argued that an inability to encode or monitor the temporal sequence of events or episodes in order to discriminate between other similar or related events (encoding what-happened-when) could result in an increased susceptibility to proactive interference and, thus, in principle expla
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However it is unclear whether
2022-04-08

However, it is unclear whether the parent and transition metal substitution in Keggin-type phosphomolybdic Tie2 kinase inhibitor will reveal the best effects on α-glucosidase. Therefore, the Keggin-type H3PMo12O40 (abbreviated as PMo12) and three transition metal-substituted POMs (Na4PMo11VO40, Na6P
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br Acknowledgments br The authors would like
2022-04-08

Acknowledgments The authors would like to acknowledge the technical assistance of J. Lee. This work was supported by the U.S. National Institute of Health grant HL111206 (to R.A.H.) the Italian Ministry for University and Research (MIUR 2010329EKE). Introduction The liver plays a vital role
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Introduction Human pathogenic Leishmania protozoa comprise d
2022-04-08

Introduction Human pathogenic Leishmania protozoa comprise 20 different species that are distributed throughout the world and cause the disease leishmaniasis [1]. Transmission primarily occurs through the bite of a female sand fly and clinical manifestations of the disease span from cutaneous lesio
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In Solloway and colleagues reported that mice
2022-04-08

In 2015, Solloway and colleagues reported that mice with alpha cell hyperplasia due to inactive hepatic glucagon receptor signaling may most likely be caused by amino NVP-CGM097 dependent mechanisms [11]. The authors then showed these adaptations are regulated by ‘mechanistic target of rapamycin’ (m
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br Conclusion br Ethics statements
2022-04-08

Conclusion Ethics statements file Conflict of interest Acknowledgements This study was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korean Government (MSIP) (Nos. 2011-0030074 and 2018R1D1A3B07050361) and Sookmyung Women’s University Specialization Pro
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However ghrelin has a short half life
2022-04-08

However, ghrelin has a short half-life of 15–20 min, because it is a natural peptide containing 28-amino acids, its clinical usefulness as a therapeutic agent may be limited (Mosińska et al., 2017; Vestergaard et al., 2007). Hence, many efforts have been made to elucidate the smallest segment of ghr
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Some previous findings indicate that GALP
2022-04-07

Some previous findings indicate that GALP has an influence on AVP and OT secretion from the posterior pituitary gland. Cunningham et al. (2004) noted that the expression of GALP mRNA was increased in the neurohypophysis of lactating rats compared to non-lactating rats, whereas GALP mRNA expression i
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In this study we describe the expression of
2022-04-07

In this study, we describe the expression of galr2a and galr2b in zebrafish embryos using whole-mount in situ RNA hybridization. To further analyze the distribution of GALR2b and its interactions with galanin, we generated Tg(galr2b:egfp) zebrafish, which express EGFP under the control of a galr2b p
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Galanin was shown to play an important role in pain
2022-04-07

Galanin was shown to play an important role in pain and pain processing [14] and the involvement of neuropeptides in the development of migraine is well established [[24], [25], [26]], however, so far it has not been examined whether systemic galanin levels correlate with migraine. Therefore, we use
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br Conclusions br Introduction Bioinformatics analysis shows
2022-04-07

Conclusions Introduction Bioinformatics analysis shows that there are about 300,000 G-rich sequences in human genome if searching with the consensus sequence (G3+N1-7G3+N1-7G3+N1-7G3+) [1], and their localizations are non-random. These G-rich sequences always localize in functional regions, su
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In summary the SAR of a series of phenylpropanoic acid
2022-04-07

In summary, the SAR of a series of phenylpropanoic acid-free fatty g proteins receptor agonists is described which resulted in the identification of potent FFA4 agonists. The superior pharmacokinetic properties of compound led to its selection as an in vivo tool compound which afforded robust effi
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Seliciclib sale Sensitivity to EphB TKI was also
2022-04-07

Sensitivity to EphB3 TKI was also demonstrated in a colon cancer cell line, COLO 205, with high expression of EphB3. We found not only exogenous but also endogenous EphB3 protein was expressed in the COLO 205 Seliciclib sale after transient transfection of pCMV6-AC-GFP/EphB3, and both were demonstr
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Although unexpected based on our predictions low
2022-04-07

Although unexpected based on our predictions, low baseline and post-stress cortisol being associated with high anxiety has been previously documented in both clinical and healthy populations of humans (Beaton et al., 2006; Jezova et al., 2004; Shirotsuki et al., 2009; Vingerhoets et al., 1996), and
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Several studies have indicated that PLD regulated PA
2022-04-07

Several studies have indicated that PLD-regulated PA signaling intersects with Rho-mediated cytoskeletal remodeling to drive mesenchymal-like cellular features, and it is known that Rho signaling has the potential to induce YAP/TAZ nuclear activity. Accordingly, Han et al. (2018) provide evidence th
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