• Fig summarizes the underlying mechanism

  2022-01-15

  

  Fig. 7 summarizes the underlying mechanism of SB on inhibiting inflammation and maintaining epithelium barrier integrity in the TNBS-induced colitis model. Our findings not only explained the protective effect of SB on colon health, but also provided evidence that GPR109A likely constitutes a valid

• br Materials and methods br

  2022-01-15

  

  Materials and methods Results and discussion We recently found that the GlyT1 N-terminal and C-terminal sequences could be modified by phophorylation, or partially lost under pathological conditions by calcium-dependent proteolysis (Baliova and Jursky, 2005, Baliova and Jursky, 2010). While re

• Here we reported series of carbohydrate modified compounds

  2022-01-15

  

  Here, we reported series of carbohydrate-modified compounds containing a dibromo substituted benzene ring which was derived from the red alga (). The conformation flexibility of Nitecapone and their polyol structures give them many unique biological properties as we have described earlier. More inte

• In the present study we tested glucosidase and tyrosinase in

  2022-01-15

  

  In the present study, we tested α-glucosidase and tyrosinase inhibitory effects of the methanol extract from lower stems and Cytochalasin J of Q. coccifera (1) as well as the isolated compounds [lyoniresinol-9-O-β-xylopyranoside (2) and lyoniresinol-9-O-β-glucopyranoside (3), cocciferoside (4), (-)

• SGLT inhibitors have been accepted as

  2022-01-15

  

  SGLT-2 inhibitors have been accepted as a new class of antidiabetic agent (Kurosaki and Ogasawara, 2013). They limit renal glucose reabsorption and promote urinary excretion of glucose, thereby reducing plasma glucose levels (de Leeuw and de Boer, 2016, Jojima et al., 2016, Pérez López et al., 2010,

• br Acknowledgments The authors would like to thank principal

  2022-01-15

  

  Acknowledgments The authors would like to thank principal investigator Edward John Pratt, MD (Lilly-NUS Centre for Clinical Pharmacology, Singapore) and study investigator Martha Hernandez-Illas MD (QPS-MRA) along with site staff, and trial participants and their families. We thank Zvonko Milicev

• In this study we demonstrate that the ETS transcription fact

  2022-01-15

  

  In this study, we demonstrate that the ETS transcription factor ETV5 is involved in the regulation of ghrelin system in response to the altered nutritional state. In the recent multiple GWAS studies, three single nucleotide polymorphisms (SNPs) of ETV5, rs7647305 (Thorleifsson et al., 2009; Willer e

• Ligand selectivity may directly be related

  2022-01-14

  

  Ligand selectivity may directly be related to the conformational landscape explored by GPCRs despite that most GPCRs do not require dimerization for ligand recognition (Mary et al., 2012). Monomer FPRs have traditionally been perceived as receptors that can recognize N-formyl peptides and LXA4. This

• Recently Bristol Myers Squibb and Merck reported their GPR a

  2022-01-14

  

  Recently, Bristol-Myers Squibb and Merck reported their GPR40 agonist research focused on the modification of α,β-position of phenylpropionic minocycline hydrochloride derivatives. For example, in recent published patent applications, Bristol-Myers Squibb claimed the pyrrolidine and dihydropyrazole

• In this study according to the critical pharmacophore T

  2022-01-14

  

  In this study, according to the critical pharmacophore T31, Y113 and R140 of FBPase, using the strategy of pharmacophore-based virtual screening, a series of novel scaffold inhibitor targeted the AMP binding site of FBPase were screened, their inhibitory activities against FBPase were further tested

• br Hippo Signaling in Autoimmunity An imbalance

  2022-01-14

  

  Hippo Signaling in Autoimmunity An imbalance of T cell subsets, such as immunosuppressive regulatory T FPH1 (Treg) and inflammatory TH17, has a key role in autoimmune diseases. Recently, investigations found that TAZ but not YAP enhances TH17 differentiation but attenuates Treg differentiation [

• DBIBB The following are the supplementary data related to

  2022-01-14

  

  The following are the supplementary data related to this article. Authorship SLC and CGE performed the study conception and experimental design, wrote the paper and directed the activities of this work. ESM and JICA performed most of the degranulation assays, [Ca2+] measurements regarding to the

• All HFD fed groups in our study

  2022-01-14

  

  All HFD fed groups in our study, having significantly higher levels of EE (heat production) is consistent with previous studies [91], where a significant increase in EE was observed within just one week of HFD feeding [81]. It is hypothesized that this phenomenon is due to the increased body mass an

• The first hypothesis better fertility in heifers that had CL

  2022-01-14

  

  The first hypothesis, better fertility in heifers that had CL at day 0, was clearly supported by our results. Heifers with a CL had over 60% P/AI compared to ∼50% in heifers without CL. These results are consistent with several other studies reporting that cycling heifers have greater fertility than

• br Materials and methods br Results and

  2022-01-14

  

  Materials and methods Results and discussion We recently found that the GlyT1 N-terminal and C-terminal sequences could be modified by phophorylation, or partially lost under pathological conditions by calcium-dependent proteolysis (Baliova and Jursky, 2005, Baliova and Jursky, 2010). While re

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