• Molecular imaging that provides a non invasive means to

  2020-02-20

  

  Molecular imaging that provides a non-invasive means to visualize and measure a biological process of interest at the molecular and cellular level in living subjects has emerged as a promising approach for in vivo detection of enzyme activity in recent decades [6]. In 543 to anatomical imaging, whi

• br Acknowledgements This research was supported by Slovenian

  2020-02-20

  

  Acknowledgements This research was supported by Slovenian Research Agency (ARRS). We thank prof. R. Marinšek Logar for helpful advice, Dr. T. Kranjc for help with data management, N. Vrhovnik and G. Lavrič for technical help with preliminary growth experiments and dr. J. Burkeljca for help with g

• DSBs can be repaired by

  2020-02-20

  

  DSBs can be repaired by two major pathways: canonical non-homologous end-joining (c-NHEJ) and homologous recombination (HR) (Chapman et al., 2012). c-NHEJ comprises two sub-pathways, a resection-independent process and a resection-dependent process, and can rejoin break ends with little or no sequen

• No effect on the A production by secretase was observed

  2020-02-19

  

  No effect on the Aβ production by γ-secretase was observed at 50μM, the highest effective concentration used in cultured (-)-Huperzine A receptor by the study of Flajolet et al. IC261 did also not exert a modulatory effect on the production of Aβ, Aβ and Aβ species in the cell-free assay at this co

• br Materials and methods br Results br Discussion

  2020-02-19

  

  Materials and methods Results Discussion Persimmon tannin has been reported to have the bile acid binding ability in vitro (Matsumoto et al., 2011) and hypolipidaemic effects in animals (Matsumoto et al, 2008, Zou et al, 2012). Our previous study also proved that persimmon tannin promoted t

• Perturbations in cell cycle are known to

  2020-02-19

  

  Perturbations in PPACK Dihydrochloride are known to induce apoptosis. Our results show that a fraction of the DT40YB-1b+/− cells, in addition to becoming tetraploids, undergo apoptotic cell death. Similar observations linking polyploidy and apoptosis have been made in the past [23], [30], [31], [32

• The potential existence of ER stress was first examined

  2020-02-19

  

  The potential existence of ER stress was first examined in EVTs in placental bed biopsy specimens obtained from pregnancies complicated by early-onset preeclampsia. It was then tested whether ER stress can modulate MMP-2 activity before elucidating the role of proinflammatory cytokines in the induct

• br Mass spectrometry based technologies

  2020-02-19

  

  Mass spectrometry-based technologies Oxysterols tend not to be observed in global lipidomic analysis, whether shot-gun based electrospray ionisation – mass spectrometry (ESI-MS) or liquid chromatography (LC)-MS based. This is because of their comparatively low-abundance and poor ionisation chara

• While oxysterols were most extensively studied for its

  2020-02-19

  

  While oxysterols were most extensively studied for its potent ability to mediate feedback regulation of cholesterol biosynthesis, some early investigations showed that the enzymes involved in its syntheses were highly upregulated in macrophages and dendritic cells—an indication of possible roles in

• Why are Tfh cell dynamics so fundamentally different in naiv

  2020-02-19

  

  Why are Tfh cell dynamics so fundamentally different in naive and immune animals? Initially, GC Crotaline must pass stringent affinity and specificity checkpoints to ensure only high-affinity non-self-reactive cells are selected. Therefore, restricting primary Tfh cells with the greatest helper cap

• Additional derivatives were synthesised using a modified app

  2020-02-19

  

  Additional derivatives were synthesised using a modified approach (). Commercially available 4-bromo-2-methoxyaniline () was converted into the boronic ester , followed by a Suzuki–Miyaura cross-coupling with chromenone triflate to afford the corresponding arylamine . Acylation of with chloroacety

• br Conclusion In this review we have discussed how

  2020-02-19

  

  Conclusion In this review, we have discussed how inhibition of the CK2/CDK5 signaling axis protects WM only when inhibited before ischemia, while inhibition of the CK2/AKT/GSK3β signaling axis protects WM either before or after an ischemic injury in young, aging, and old WM (Fig. 3). CK2 activati

• br Acknowledgements br Introduction Water and electrolytes c

  2020-02-18

  

  Acknowledgements Introduction Water and electrolytes constitute an integral part of all living things, and glucagon like peptide governing their movements play important roles in a wide variety of physiological and/or pathophysiological processes. Given the importance of channel proteins in c

• Accumulating evidence suggests that certain abnormal

  2020-02-18

  

  Accumulating evidence suggests that certain abnormal emotional traits, such as impulsive aggression and cluster B personality, are associated with suicidal behaviors (Currier and Mann, 2008, Mann et al., 2009, Rujescu et al., 2007, Turecki, 2005). Impulsive aggression appeared to be associated with

• Simeprevir In mammals NETs contain DNA and antimicrobial pro

  2020-02-18

  

  In mammals, NETs contain DNA and antimicrobial proteins composed mainly of nuclear histones, granule-derived neutrophil elastase, myeloperoxidase, lactoferrin, pentraxin, and gelatinase among others [11], [46], [47], [48]. In fish, NETs-like structures have been observed, and DNA staining and immuno

10916 records 567/728 page Previous Next First page 上5页 566567568569570 下5页 Last page